Rob Klose (born December 28, 1977) is a Canadian researcher and Professor of Genetics at the Department of Biochemistry, University of Oxford.

[8] Klose spent two years as a postdoctoral researcher in the laboratory of Yi Zhang, who was based at the University of North Carolina at Chapel Hill, identifying a novel family of histone lysine demethylase enzymes.

Since then, he has been a Monsanto senior research fellow, a post associated with Exeter College, Oxford, and in 2014 was appointed as professor of cell and molecular biology.

In particular, he has focused on understanding how DNA encoded regulatory elements in vertebrates, called CpG islands, help to achieve appropriately controlled gene usage.

[13] In recognition of his achievements as an early career stage scientist, he was awarded the Francis Crick Lecture by the Royal Society in 2015.