[3][4] Bigelow has provided financial support for investigations of UFOs and parapsychological topics, including the continuation of consciousness after death.

For most of his career, "he held on to almost everything he bought, but ... eventually unload[ed] much of his housing stock in the boom years immediately before the 2008 crash".

[14] In 2013, Bigelow indicated that the reason he went into the commercial real estate business was to obtain the requisite resources to be able to fund a team developing space destinations.

[16] In April 2016, Bigelow's BEAM module was launched to the International Space Station[8] on the eighth SpaceX cargo resupply mission.

[17] In March 2020, Bigelow Aerospace laid off all 88 members of staff and halted operations after over 20 years of business, in a move that was partially caused by the coronavirus pandemic.

[20] The organization researched cattle mutilation and black triangle reports, ultimately attributing the latter to secretive advanced aircraft operated by the military.

[33][34] Bigelow has contributed over $25 million[35] to groups and causes supporting Joe Lombardo's candidacy for governor of Nevada.

[36] In January 2024 he stated in an interview that he had donated to Donald Trump, "I gave him $1 million towards his legal fees a few weeks ago.