He spent the majority of his career at UCLA (1958–1991) and was the co-editor of the Annual Review of Pharmacology and Toxicology from 1977–1990.
[3] Following his PhD, he conducted postdoctoral research under E. Leong Way at the University of California, San Francisco.
He joined the faculty of the University of California, Los Angeles in 1958, where he remained until his retirement in 1991.
In particular, he studied analgesics (painkillers), including opiates, and their interactions with hormones produced by the thyroid, pituitary, hypothalamic, and adrenal glands.
[3] In 1971, he was appointed an associate editor at the Annual Review of Pharmacology and Toxicology; he was made the co-editor in 1977 along with Ronald Okun.