He is executive producer of the AMC series Robert Kirkman's Secret History of Comics, and the Korean pre-apocalyptic drama, Five Year.

[8] His first comic book work was the 2000 superhero parody Battle Pope,[4] which he co-created with artist Tony Moore, self-published under the Funk-O-Tron label, and was adapted into a season of 8 animated webisodes that appeared on Spike TV's website in 2008.

[9] Later, while pitching a new series, Science Dog, Kirkman and artist Cory Walker were hired to do a SuperPatriot miniseries for Image Comics.

While working on that book, Kirkman and E. J. Su created the 2002 Image series Tech Jacket, which ran six issues, and the one-shot title, Cloudfall.

[10] In 2005, Paramount Pictures announced it had bought the rights to produce an Invincible feature film, and hired Kirkman to write the screenplay.

In 2003, Kirkman was hired by Marvel Comics to pen a revival of the 1990s Sleepwalker series,[14] but it was canceled before being published; the contents of its first issue were included in Epic Anthology No.

[15] At Image, Kirkman and artist Jason Howard created the ongoing series The Astounding Wolf-Man, launching it on May 5, 2007, as part of Free Comic Book Day.

[21] In 2010, he also began producing the television adaption of his comic book series The Walking Dead,[22] the pilot of which was directed by Frank Darabont.

[25] On February 9, 2012, Tony Moore filed a lawsuit alleging that Kirkman, in 2005, had deceitfully engineered him into surrendering his rights to The Walking Dead comic book and eventual TV series in exchange for payments that never materialized.

"[27] Kirkman made an appearance in a 2012 episode of Adult Swim's Robot Chicken as himself where he tries to tell The Nerd and Daniel a hint, but gets eaten by the zombies.

In November 2013, Cinemax purchased a TV pilot based on Kirkman and artist Paul Azaceta's then-upcoming six-issue exorcism comics miniseries, Outcast.

[29] Kirkman was a producer of the science fiction thriller Air, which starred The Walking Dead's Norman Reedus, and Djimon Hounsou.

On April 4, 2017, it was announced that Seth Rogen and Evan Goldberg would direct/write/produce a live-action adaptation of Invincible for Universal Pictures, with Kirkman also serving as a producer on the project.

[36][37] The series stars Steven Yeun, J. K. Simmons, Sandra Oh, Mark Hamill, Seth Rogen, Gillian Jacobs, Andrew Rannells, Zazie Beetz, Walton Goggins, Jason Mantzoukas, Zachary Quinto, Khary Payton, Chris Diamantopoulos, Malese Jow, Kevin Michael Richardson, and Grey Griffin.

[39] In February 2023, it was announced that Kirkman would reunite with Lorenzo De Felici to launch Void Rivals, a new series that would kick-off a new shared comic universe.

[40] In June 2023, it was later revealed that the book would launch the Energon Universe and that Kirkman's production company, Skybound, would publish comics based on Transformers and G.I.

[46] Not stopping at nominations, the show clinched prestigious honors including Television Program of the Year by the American Film Institute in 2010 and 2012, along with IGN's Best Horror Series in 2012 and 2016.

Kirkman, in addition to serving as creator and executive producer, wrote the series premiere, the season one and two finales, as well as the special episode Invincible: Atom Eve.