He was known for playing the role of Father Mike Fitzgerald in the American sitcom television series Bridget Loves Bernie.

[2] Sampson also guest-starred in numerous television programs including Gunsmoke, The Outer Limits, Star Trek: The Original Series, Mission: Impossible, Bonanza, Dr. Kildare, Wonder Woman, Voyage to the Bottom of the Sea, Green Acres, Hawkins, The Jeffersons, and Police Story.

[2][3] He also appeared in films such as Re-Animator (as Dean Halsey), City of the Living Dead, Mr. Ricco, The Dark Side of the Moon, Robot Jox, The Sky's the Limit, Look in Any Window and Mad Dog Coll.

[6] Sampson also played the recurring role of Sheriff Turk Tobias in the television soap opera Falcon Crest.

[2] Sampson died in January 2020 in Santa Barbara, California, at the age of 86 and was interred at Oakwood Memorial Park Cemetery.