Born in Corumbá, Guilherme spent his childhood between Natal and Rio de Janeiro.

[1] During his youth he played football with Vasco da Gama and, while in the army, with the Brazilian Military Soccer National Team.

[1] Guilherme made his debut as an actor and a playwright with an amateur dramatics society in north Rio, where he was noted by a TV Rio producer, who immediately put him under contract for his channel.

[1] He later worked for TV Excelsior, where he met the comedian Renato Aragão, of whom he became the sidekick in a number of projects, notably playing Sargento Pincel in Os Trapalhões.

[1][2] He later worked for TV Record and Rede Tupi, where he met the comedian José Santa Cruz, with whom he formed the duo Jojoca e Xexéu.