Born in Pamplona, Navarre, Santamaría was a product of CA Osasuna's youth ranks, and was transferred to UD Las Palmas in summer 2006.
In the Canary Islands, he spent his first two seasons with the reserves, making his debut with the first team on 23 February 2008 in a Segunda División match against RC Celta de Vigo in which he saved a penalty kick, helping to a 1–0 home win.
During the campaign, he played as backup to also newly signed Gustavo Munúa, appearing in all of the side's four matches in the Copa del Rey.
[3] On 12 August 2010, after terminating his Las Palmas contract, Santamaría joined Girona FC in the second division, replacing Albert Jorquera who retired earlier in the summer.
[9] Santamaría entered Huesca's first season in La Liga as second choice behind Atlético Madrid loanee Axel Werner, and moved further down the depth chart when Serbian Aleksandar Jovanović was signed from Danish club Aarhus Gymnastikforening at the end of August.