[1] Siffredi is known for his rough style of pornography, often involving anal sex, spitting, slapping and choking, his collaboration with the pornographic studio Evil Angel, as well as his own productions.

[8] He moved to Paris in his early twenties and attended different sex clubs where he was eventually discovered by French porn actor and director Gabriel Pontello, who introduced him to other producers.

However, sexual frustration and disappointment as a director with his male talent and the state of the porn industry overall led Siffredi to return as a performer in 2009.

[14] Despite renewed success, Siffredi announced his retirement once again in 2015, shortly after appearing on the Italian reality television show L'isola dei famosi (The Celebrity Island), which saw him stranded naked and alone on a beach for one week.

[19] Siffredi is one of a few porn actors to enjoy crossover appeal and success with respect to other segments of the adult film industry, as well as some in mainstream media.

In June 2023, Siffredi featured in the Spring-Summer 2024 runway show of Milan-based fashion brand Dsquared², playing the role of a pornographic movie director.

[26] Siffredi is married to Rosa Caracciolo (born Rózsa Tassi), a Hungarian model whom he met in 1993 in Cannes and with whom he performed two years later in Tarzan X: Shame of Jane.

[27] Upon his decision to return to on-screen pornographic performance in 2009, Siffredi recounted, "I spoke with my wife and she said it's my problem only, it doesn't belong to her and the boys.

'"[14] However, after a long period of intensive performing, with much time away from his home in Italy, Siffredi announced his retirement again in 2015 for the sake of his marriage.

"[17] Siffredi discussed his personal life in 2015 on the reality television show L'isola dei famosi (The Celebrity Island).

Speaking of his sexuality, Siffredi discussed his sex addiction as emerging from "some kind of devil in me" and spoke of himself, "[It] sometimes sends me out of my mind."