Tommy Pistol started his career in Queens, New York, as a stage actor with sketch comedy group Cheese Theater, with whom he acted for more than a decade.

In 2015, Pistol became the first male performer in twenty years to host the annual AVN Awards in Las Vegas, Nevada, alongside Alexis Texas.

Since 2016, he has participated in the annual WIH Massive Blood Drive PSA, a collaboration between the international grassroots initiative Women in Horror Month and Twisted Twin Productions.

In September 2022, Canadian horror directors the Soska Sisters announced the premiere of their new film On the Edge, co-starring Pistol, to take place at the London FrightFest Halloween festival on October 29.

The festival synopsis of the film reads, "Family man Peter gets more than he paid for when he books a 36-hour session with the sadistic Mistress Satana who seems more intent on making him suffer for his sins.