She is best known for her role as April Malloy on ABC drama series Mistresses (2013–16) and as the voice of Rochelle in the critically acclaimed video game Left 4 Dead 2 (2009).

In 2007, Aytes guest starred in the Fox series Bones as Felicia Saroyan, the sister of Lab Supervisor, Cam.

[8] From 2010 to 2011, she had a recurring role in the ABC series Detroit 1-8-7 as prosecutor Alice Williams, until her character was murdered in the episode "Key to the City", which aired on January 11, 2011.

[9] In 2011, Aytes guest starred in three episodes as Amber James, the former girlfriend of Keith Watson, in the seventh season of ABC comedy-drama Desperate Housewives.

[10] In 2012, Aytes was cast as one of the four leads, along with Alyssa Milano, Yunjin Kim and Jes Macallan, in the ABC drama series Mistresses about the lives of four female friends and their involvement in an array of illicit and complex relationships.

[13][14] In 2013, she also began appearing as Dr. Savannah Hayes, the girlfriend of Special Agent Derek Morgan (Shemar Moore) on the CBS crime thriller series Criminal Minds.