The Rock Island Depot is a historic railroad station located at 201 East 10th Street in Sioux Falls, South Dakota.

The station opened in 1886 to serve the Burlington, Cedar Rapids and Northern Railway, a predecessor of the Rock Island.

The ashlar and wood building has a Richardsonian Romanesque design with a side-facing stone gable and an octagonal turret.

As the railroad network spread through South Dakota, Sioux Falls became the state's primary commercial and transportation hub due to its established station.

[1] This article about a property in South Dakota on the National Register of Historic Places is a stub.