The bay opens onto the Coral Sea, part of the South Pacific Ocean.

Adjacent to the bay is the Girramay National Park, south of which is the town of Cardwell.

[3] The bay was significant in the exploration of the Cape York Peninsula by Edmund Kennedy in 1848.

He was landed here with a group of twelve men, to begin the journey north.

On the way, Kennedy left eight members of the expedition at Weymouth Bay, intending to pick them up later on the return by sea.