In 1974, Bryden founded Systemhouse Ltd., a computer integration firm where he served as president or chairman until 1991.
In 1992, Bryden became CEO of Terrace Corporation, the principal owner of the new Ottawa Senators NHL franchise.
In 1996, Bryden formed the WorldHeart Corporation in coalition with the University of Ottawa Heart Institute, Dr. Tofy Mussivand and Dr. Michael Cowpland.
Bryden agreed to pay creditors a total of $600,000 on the debt, which was induced by high player salaries and an unfavourable exchange rate against the US dollar.
[2] In 2005, Bryden was appointed as the new chairman of cancer drug developer PharmaGap, Inc. Until 2014, he was President and CEO of Plasco Energy Group, an Ottawa firm developing energy production using plasma gasification, from household waste.