Rodrigo Manrique de Lara (1406 – November 11, 1476, Ocaña, Spain) was a rebellious Spanish noble who gained notoriety for his prowess in the Reconquista battles against the Muslim invaders.

Rodrigo spent the bulk of his life in conflict with his arch enemy, Álvaro de Luna, in defense of his possessions and titles.

After John II's death in 1454, he began to actively participate in the noble league fighting against Henry IV of Castile.

He was present for the signing of the Treaty of the Bulls of Guisando which officially recognized Henry IV of Castile as the lawful king and his sister Isabella as the heir to the throne.

In 1474, with the ascension to the throne of his patron, Isabella I of Castile, Rodrigo was named Grand Master of the Order of Santiago in the town of Uclés.

King Ferdinand II of Aragon stepped into the argument and mediated this division which ended upon the death of Pedro Manrique two years later in 1476.