[1] This noble house merged with the House of Mendoza, which subsequently adopted its motto "Ave Maria, Gratia Plena", after the marriage of Leonor Lasso de la Vega, the daughter and only heir of Garci Lasso Ruiz de la Vega, and Diego Hurtado de Mendoza, the Head Admiral of Castile.
After this union, the Lordship of the House of de la Vega was passed on as property of his successors, the Dukes of the Infantado.
They were able to set up a system of Mayordomazgos independent of the crown and based in the Castillo de Pedraja, which belonged to the family.
During this time, there were a great many power struggles going on in the area of Cantabria, creating a number of social conflicts.
[2] After the merger with the House of Mendoza, the Cantabrian surname "Lasso de la Vega" was passed on through the maternal line at later times throughout the years and is associated with various soldiers, poets, and Golden Age writers such as Garcilaso de la Vega, the soldier and poet, and Inca Garcilaso, the historian from the Viceroyalty of Peru.