From 1803 she made two complete voyages as a slave ship in the triangular trade in enslaved people.

1st enslaving voyage (1803–1805): Captain William Thompson sailed from Liverpool on 9 December 1802.

[4] She returned to Liverpool with 525 bags of coffee, 700 billets of barwood, and 112 elephant teeth (ivory tusks).

[5] 3rd slave voyage (1805–loss): Captain Edward Newby acquired a letter of marque on 8 February 1805.

Roehampton did not appear again in Lloyd's List or other newspapers that published ship arrival and departure data.