[3] In 1991, Hyatt produced and released the band's second album, Vital Signs 2, distributed by EMI Pakistan, which received mixed reviews.

[3] In 1998, Hyatt discontinued Vital Signs after facing various issues, parting with fellow band member Junaid Jamshed to focus on his solo career.

[2] In 2008, Hyatt founded the international music outlet, Coke Studio, and he is credited with featuring both established and upcoming Pakistani artists through the platform.

[2] However, his interest in producing and playing Western music began after his aunt bought Pink Floyd's The Wall album in 1980, which he frequently listened to.

[3] Bassist Nusrat Hussain, whom he cites as a major influence in learning and on his outlook on music along with the global acts of that era, was a member of Progressions, while Shahi was in Crude X.

He participated with his band Mole in the third episode of Coke Studio season four with the instrumental "Baageshri",[4] while later composing the background score of the 2019 action-thriller movie Laal Kabootar.

[5][6] In the midst of 1980s, Hyatt partnered with Shahzad Hasan (Shahi) to begin working on the rock/pop music genre; both launched Vital Signs in 1986.

[7] Earlier in 1983, Hyatt met Junaid Jamshed who sang "Careless Whisper", a 1984 single by George Michael, at the Islamabad Model College.

"[12] Hyatt's plans for the show were met with some skepticism initially, and he was allowed to produce only three or four songs for the first season of Coke Studio Pakistan.

So that was liberating, and of course that led to a process of self-discovery.... As producer, Hyatt is said to have brought a psychedelic vibe to the show[11] and has been praised for infusing energy and creativity into Coke Studio's production.

[18] Hyatt is also acknowledged for facilitating "creative collaborations between two different dimensions of music, the established contemporary Western artists alongside regional, folk, classical ones..." as well as for scouting and promoting new talent through the show.

[19] Writing for The News on Sunday, Maheen Sabeeh contended that "under Rohail Hyatt’s days as producer, Coke Studio became something of a phenomenon, both in Pakistan and outside that was both cool enough for the youth and appealed to an older generation as well.

[22] Hyatt stated: "the idea was representation of all people who called Pakistan their homeland and not restrict it to a certain class or religion but make sure that it puts minorities front and center along with the majority.