Born in November 1958 to Usha and Kamal Khosla in an affluent Punjabi Hindu family, Rohit had always dreamed of becoming a fashion pioneer.

[3] He is quoted in his biography Vanguard, penned by Rohini Khosla, studying in England was pure bliss -- ideas just flowing, fabrics everywhere and fashion obsessive people all around me.

In 1987, he co-founded Ensemble, India's popular designer label store in New Delhi,[8] with Tarun and Sal Tahiliani, which started with five labels: Tarun Tahiliani, Rohit Khosla, Neil Bieff, Amaya, Abu Jani and Sandeep Khosla.

[6] Many leading fashion designers of India trained under Rohit Khosla, including Aparna Chandra, Ranna Gill,[9] Sonam Dobal [10] and JJ Valaya.

[12] In 2007 the India Fashion Week paid a tribute to him, with designers like Rohit Bal dedicating his collection to him.