[7] In September 2018, after François de Rugy's appointment to the government, Lescure supported Richard Ferrand's candidacy for the presidency of the National Assembly.

[9][10] Following the 2022 legislative elections, Lescure stood again as a candidate for the National Assembly's presidency;[11] in an internal vote, he lost against Yaël Braun-Pivet.

[12] In July 2019, Lescure voted in favour of the French ratification of the European Union’s Comprehensive Economic and Trade Agreement (CETA) with Canada.

[13] In 2021, Lescure publicly criticized Minister of the Economy and Finance Bruno Le Maire, arguing that the Castex government's rejection of a proposed $20 billion takeover of Carrefour by Canada’s Alimentation Couche-Tard was due partly by a desire to control domestic food supplies.

[14] In January 2021, as a member of the "Hunting, fishing and territories" study group, the deputy voted in favor of the defense and promotion of hunter's leisure.