Between 2007 and November 2011, Roma Tiburtina was subject to an extensive redevelopment programme, during which much of the original station building and infrastructure were demolished and replaced, and new on-site facilities established.

[8] On 18 October 1943, two days after the Raid of the Ghetto of Rome, about 1035 Jews were brought to Tiburtina station, loaded onto Holocaust trains and deported to Auschwitz concentration camp.

[9] As a result of repeated aerial bombardments of Rome during the Second World War, the station suffered extensive damage, including to the recently completed main building.

[7] While Roma Tiburtina station is regarded as being a heavily trafficked transit hub, even greater passenger numbers have been recorded at the more centrally located Termini.

[10] In October 2003, Sally Baldwin, a visiting British University professor, was killed at the station when an escalator fell apart and a hole suddenly appeared beneath her feet.

[7] As designed, the new Roma Tiburtina takes the form of a large bridge spanning across the railway lines and connecting between the Nomentano and Pietralata districts.

[7] The suspension of the main structure offers several advantages, including a greater level of isolation from the noise and vibration generated by the passage of trains beneath it.

[17] As a result, serious and unavoidable disruption to services occurred, including a temporary partial closure of Metro line B, between Castro Pretorio and Monti Tiburtini.

[18] The fire damaged equipment within the relay room, rendering the majority of controls for nearby tracks and traffic signals alike unusable, leaving a vital part of the Italian rail network disabled; reportedly, this led to significant train delays throughout the country.

[19][20][21] Furthermore, the damage to the structure had reportedly rendered the station building in danger of collapse; due to the impact of the fire, further problems and service delays that occurred for many months afterwards were attributed to the accident.