The episcopal residence and seat of the vicariate is the Santo Niño Cathedral located in Calapan.

[4] On November 13, 2018, Pope Francis has appointed Nestor Adalia, currently the Vicar General of Calapan, to take the post as apostolic administrator "ad nutum Sanctae Sedis", meaning "at the disposition of the Holy See" or to take temporary charge of the administration of the apostolic vicariate, due to the health condition of Warlito Itcuas Cajandig.

On June 29, 2023, Pope Francis appointed Moises Magpantay Cuevas (previously as Auxiliary Bishop of Zamboanga) as the 6th Apostolic Vicar of Calapan.

The Apostolic Prefecture of Mindoro was created on July 2, 1936, with territories taken from the Roman Catholic Dioceses of Jaro and Lipa, both of which were later elevated into archdioceses.

[2] On December 19, 1974, and January 27, 1983, portions of its territory was lost to the creation of the Diocese of Romblon and the Apostolic Vicariate of San Jose in Mindoro.