The Roman Catholic Metropolitan Archdiocese of Santiago de los Caballeros (Latin: Archidioecesis Metropolitae Sancti Iacobi Equitum) is a Latin Rite Metropolitan Archdiocese in the Dominican Republic.

As per 2014, it pastorally served 1,118,000 Catholics (83.7% of 1,336,000 total) on 3,633 km² in 89 parishes and 17 missions with 125 priests (74 diocesan, 51 religious), 132 deacons, 350 lay religious (136 brothers, 214 sisters) and 37 seminarians.

The Metropolitan has the following suffragan sees : (all Roman Rite)

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