The Diocese of Santa Clara is a diocese of the Latin Church of the Roman Catholic Church in Cuba.

The diocese is a suffragan of the Archdiocese of Camagüey.

Originally erected as part of the Diocese of Cienfuegos in 1903, the parent diocese was renamed to the Diocese of Cienfuegos-Santa Clara in 1971.

Finally in 1995 the parent diocese was split to form the Diocese of Cienfuegos and the Diocese of Santa Clara.

This article about a Catholic diocese is a stub.