Bishop James Roman Boiragi, who was a local priest, now he leads the diocese.

The bishopric was created on 3 January 1952 as the Diocese of Jessore, as a suffragan of the Metropolitan Archdiocese of Calcutta in India.

Since the elevation of the Diocese of Chittagong to Archbishopric in February 2017, Khulna became one of it two original suffragans.

Of special historical interest is Iswaripur, which is fifty miles south of Satkhira town.

There was no other Christian Church in the area comprising the present Khulna Diocese until the arrival of the PIME Missionaries in 1856.