The Roman Catholic Diocese of San Andrés Tuxtla (Latin: Dioecesis Sancti Andreae de Tuxtla) (erected 23 May 1959) is a suffragan diocese of the Archdiocese of Jalapa.

In 1962, it lost territory to form the Archdiocese of Jalapa and the Diocese of Veracruz.

It also lost territory in 1984 with the formation of the Diocese of Coatzacoalcos.

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