The Roman Catholic Diocese of Uromi (Dioecesis Uromiensis) in Uromi, Edo State, Nigeria was created on December 14, 2005, when it was split off from the Archdiocese of Benin City.

Its first bishop was Augustine Obiora Akubeze (who was named Archbishop of Benin City in March 2011).

The St Anthony of Padua church in Uromi was selected to be its cathedral.

The canonical erection of the diocese and the episcopal ordination of the bishop took place on Saturday, February 25, 2006.

Neighboring dioceses are Auchi to the north, Issele-Uku to the south and Benin City to the west.