Karmazin suffered his first loss in 2002, a twelve-round decision against Javier Castillejo of Spain in Castiliejo's hometown.
His only draw came early in his career in an eight-round fight against Javier Martinez in Avilés, Spain.
The 2004 bout was halted when Papillion was cut by an accidental headbutt in the fourth round.
In 2004, Karmazin outworked Keith Holmes to a majority decision in an IBF title eliminator.
A consistent puncher, Karmazin won the IBF Light Middleweight championship through steady work that led to a lopsided unanimous decision over Kassim Ouma.