[2][3] He won the 1950 Kentucky boys high school doubles tennis championship with fellow St. Xavier 1951 alumni George D.

After five years of debate and compromise, the Simpson-Mazzoli Bill was ultimately signed into law in November 1986.

The 104th United States Congress, the first in nearly a quarter century without Mazzoli, passed legislation (P.L 104–77), signed by President Bill Clinton on December 28, 1995, renaming the Federal Building in his hometown of Louisville, the Romano L. Mazzoli Federal Building.

In 2002, Mazzoli was a Fellow at the Institute of Politics at Harvard University's John F. Kennedy School of Government.

While studying for his degree, he lived on campus, where he met Pete Buttigieg, then an undergraduate student.

[3] In September 2006, Simpson and Mazzoli co-authored an article that appeared in The Washington Post revisiting their 1986 immigration legislation.