Rome was a short-lived postbellum frontier settlement in Big Creek Township, Ellis County, Kansas, United States.

It is notable for its association with the early plains career of its co-founder, William Frederick "Buffalo Bill" Cody.

[2][3] In 1868, the Clarkson Brothers, Charlie, Matthew, and George, set their buffalo hunting headquarters at the abandoned Rome site.

At the 1876 Centennial Exposition, Cody convinced I. M. Yost (the husband of a cousin) to build a water-powered grain mill at Rome.

The combination of the high track with the deeply cut ravine of Big Creek surrounding the remaining boundaries of Rome resulted in the derisive nickname "The Walled City".

In 1867, the Ellis Trail passed along the north side of the town, crossing Big Creek at the east and west ends.