He coined the term POPaganda to describe a mash-up of high and low cultural touchstones, from superhero mythology to totems of art history, populated with his original characters, including MC Supersized, the obese fast-food mascot featured in the movie Super Size Me, and Abraham Obama, the fusion of America's 16th and 44th Presidents.

Other characters in English's paintings, billboards, and sculpture include three-eyed rabbits, cowgirls and grinning skulls – visual, with humorous undertones.

English was interviewed for the documentary Super Size Me (2004), which showed his McDonald's-themed artwork—inspired by his belief about the effect of fast food franchises and restaurant chains on American culture – "MC Supersized".

[12] English and his fellow artists Shepard Fairey, Kenny Scharf and Robbie Conal guest-starred on the March 4, 2012, episode of The Simpsons, "Exit Through the Kwik-E-Mart".

[13] In November 2021 English's giant immersive instillation Sugar Circus opened in Shenzhen, PRC marking the beginning of the exhibitions world tour.

[16] Ron English street art activities are the subject matter and covered extensively in the Pedro Carvajal documentary titled Popaganda.

Some of English's product packaging designs include, "Cap'n Corn Starch", "Duncan High Hash Brownies" and "Camel Kool's" THC Enriched Tobacco Cigarettes.

Frequent themes are revisiting and reworking childhood with adult skill as well as examining the darker meanings behind garish pop surface imagery.

These include a reworking of Charlie Brown into his "Grin" character and one of his famous "MC Supersized" based on the idea that Ronald McDonald ate his own product.

[26] In 2011 he exhibited "Skin Deep: Post-Instinctual Afterthoughts on Psychological Nature", a new body of works exploring the inner lives of iconic figures, at Lazarides in London that represents the artist.