Villone played for 12 teams in his career, tied for 3rd all time with pitcher Mike Morgan and outfielder Matt Stairs, and trailing only Octavio Dotel and Edwin Jackson.

[3] He attended the University of Massachusetts Amherst and was a two-sport star, playing baseball and football.

Because of his stellar 1994 campaign, Seattle promoted him, effective at the start of the 1995 season, to their AAA affiliate, the Tacoma Rainiers.

He made his Major League debut on April 28, 1995, working a scoreless ninth inning against the Detroit Tigers.

On July 31, 1995, Seattle dealt Villone and Marc Newfield to San Diego in exchange for Greg Keagle and Andy Benes.

He started the 1996 season with San Diego’s then AAA Affiliate, the Las Vegas 51s.

On July 31, 1996, the Padres shipped Villone, Bryce Florie, and Marc Newfield to the Milwaukee Brewers for Gerald Parent and Greg Vaughn.

[10] Before the 1999 season started, Villone and the Indians agreed to a one-year contract worth $462,500.

He walked more batters (78), struck out less (77), allowed more hits (154), and had a higher earned run average (5.43) than the 1999 season.

[15] He continued to struggle, going 5–7 with a 5.56 earned run average as a spot starter/long reliever on the Astros’ pitching staff.

[17] On July 15, Villone broke the sesamoid bone in the big toe of his landing leg while covering first base.

Again, Villone was used in a long relief/spot starter role, something that he was accustomed to from his days with Houston, Colorado, and Pittsburgh.

Used primarily as a lefty specialist, he pitched 401⁄3 innings, allowing 33 hits, 23 walks, and 41 strikeouts.

On July 31, 2005, the Mariners sent Villone to the Florida Marlins in exchange for Yorman Bazardo and Mike Flannery.

In December 2005, the Marlins traded Villone to the New York Yankees for left-hander Ben Julianel.

[27] In February 2008, Villone was signed by the St. Louis Cardinals to a minor league contract and was invited to spring training.

[29] On February 27, 2009, Villone signed a minor league contract with the New York Mets and was invited to spring training.

[32] He then signed a minor league deal with the Washington Nationals on April 10 and was assigned to Triple-A Syracuse.

[37][38] During a July 23, 2010, game with the Durham Bulls, Villone took the mound in the eighth inning with a one-run lead but gave up a walk to what would become the tying run.

He then threw to first base 12 times to hold the runner, without once throwing to home plate, annoying the crowd who booed Villone mercilessly.

[40] Cut from the Nationals before the regular season started, Villone then signed with the Somerset Patriots of the independent AA Atlantic League.

[41] He became the pitching coach of the Chicago Cubs' Single-A affiliate, the Peoria Chiefs, in 2012.

[42] In December 2012, Villone was announced as the pitching coach for the Cubs' new Single-A affiliate, the Kane County Cougars, where he spent the 2013 season.

[43] In December 2013, he was promoted to pitching coach for the Daytona Cubs of the Class A-Advanced Florida State League.

Villone is now married to his wife Brooke and resides in Upper Saddle River, New Jersey.

His wife Brooke appears on the VH1 reality show "Baseball Wives", which premiered in 2011.