He broke out as a star pitcher and batter during his junior season at Grossmont High School, which he helped take to two state championship appearances.

After being selected by the Blue Jays in the first round of the 2011 MLB Draft, Musgrove chose to forgo his previous commitment to play college baseball for San Diego State, instead signing with the team.

[5] He was frequently busy, working as a police officer and private investigator in San Diego, California so Diane played catch with a young Musgrove in their front yard.

Johnson taught Musgrove a series of intense workouts designed in the 1970s by former Philadelphia Phillies trainer Gus Hoefling.

[7] Musgrove attended Grossmont High School in El Cajon, where he emerged as a strong two-way player during his junior season, playing alongside future Pittsburgh Pirates teammate Steven Brault.

[8] As a pitcher in 2010, Musgrove boasted an 11–1 win–loss record with five saves, a 2.07 earned run average (ERA), and 70 strikeouts in 77+2⁄3 innings pitched.

[17] An injury to his sternoclavicular joint continued to bother Musgrove during his time with the ValleyCats, and he made only a handful of appearances.

[18] Musgrove started the 2015 season with the Single–A Quad Cities River Bandits, with whom he posted a 4–1 record and a 0.70 ERA in five games.

[19] He received two promotions that season: first, in May, to the High-A Lancaster JetHawks, and then again in June to the Double –A Corpus Christi Hooks.

[12] He was named the Astros' 2015 Minor League Pitcher of the Year, and was added to the 40-man roster in November so that he could be protected from the Rule 5 draft.

[22] He made his major league debut on August 2 versus the Toronto Blue Jays, striking out eight over 4+1⁄3 innings while only allowing one hit.

[24] On January 13, 2018, the Astros traded Musgrove, along with Michael Feliz, Colin Moran and Jason Martin, to the Pittsburgh Pirates in exchange for Gerrit Cole.

[29] On January 19, 2021, the Pirates traded Musgrove to his hometown San Diego Padres in a three-team trade that sent David Bednar, Omar Cruz, Drake Fellows, Hudson Head, and Endy Rodríguez to the Pirates and Joey Lucchesi to the New York Mets.

[30] The 2021 season proved to be a breakout campaign for Musgrove, as he posted career bests in several categories, including ERA, WHIP, batting average against, strikeouts, innings pitched, and win/loss record.

[38] Musgrove began the 2024 campaign out of San Diego's rotation, compiling a 3–4 record and 5.66 ERA with 44 strikeouts across 10 starts.

[41] On October 2, Musgrove was pulled from a Wild Card series start against the Atlanta Braves in the fourth inning with what was initial reported as elbow tightness.

The feat became the fastest pitch thrown in the coldest continent on Earth, and was done in support of the Challenged Athletes Foundation.