Thomas Charles Byde Rooke (18 May 1806 – 28 November 1858) was an English physician who married into the royal family of the Kingdom of Hawaii.

He built a mansion called the Rooke House in Honolulu that became popular with political and social leaders of the Kingdom.

The family lived upstairs, in a style redolent of a British manor house, with red Kashmir carpets, mahogany and dark oak furniture, and framed oil paintings.

It was on the ma kai-Waikiki (southwest) corner of Beretania and Nuʻuanu Avenue and bordered by Fort Street and Chaplain Lane, 21°18′41″N 157°51′36″W / 21.31139°N 157.86000°W / 21.31139; -157.86000 (Rooke House).

Much later, the house witnessed the death of two others of the Young family: James Kānehoa, Grace Rooke's half-brother, and Kaʻōanaʻeha, her mother.

Grace Rooke, steeped in her mother's aliʻi tradition of hoʻokipa (hospitality), was a gracious hostess.

Dr. Rooke, always elegantly attired, complemented his naturally shy wife with his open, gregarious, and forthright manner.

The residence was the scene of mass gatherings of Hawaiians and some British with chants celebrating Emma's rightful claim to the throne.

[7] He was a founding member of the first Hawaii Medical Association, along with Charles Guillou, William Hillebrand and Gerrit P. Judd in 1856.