The series is centered around two gamers who are members of the same party in the MMORPG Dragon Quest X. Takumi Satsuki, a man in his early 20s who plays the game using a female Poppet avatar named Powder, and Miyako Okamoto, a gyaru who plays the game using a male Ogre avatar named Goro.

The two befriend each other while playing DQX, and decide to move in to a shared house complex, without any prior knowledge of the other's real gender.

Written and illustrated by Renjuro Kindaichi, Rooming with a Gamer Gal began serialization on Square Enix's Gangan Online manga website on June 20, 2014.

The series starred Amane Okayama as Takumi Satsuki (Powder) and Tsubasa Honda as Miyako Okamoto (Goro).

[14][15][16] In 2019, the series, alongside Oni o Kau, won the Men's Comic Prize at NTT Solmare's "Minna ga Erabu!!