It runs under this name from Columbus Drive at the southern end of Grant Park to the western city limits,[1] then continues through the western suburbs including Lombard, Wheaton and, West Chicago until it reaches Geneva, where it is known as State Street.

[1] The road begins at Lake Shore Drive and heads west, forming the southern boundary of the Chicago Loop.

Continuing west, it passes the University of Illinois at Chicago's two campuses and St. Ignatius College Preparatory School between Halsted Street and Damen Avenue.

301 Roosevelt Road is a Pace bus route that runs from Wheaton station on Metra's Union Pacific West Line (from the new DuPage County Courthouse further west under limited service) to Forest Park station on the Blue Line.

[5] The Chicago 'L' Roosevelt station is a stop and transfer point on the Red, Green and Orange lines.