He is currently CEO and co-founder of Epicore Biosystems, research associate professor at Northwestern University's Biomedical Engineering Department, and Director of Translational Research in the Querrey Simpson Institute for Bioelectronics.

He then completed his PhD research and training at the Harvard–MIT Program in Health Sciences and Technology (HST) in 2008.

[1] Upon completion of his PhD degree, Ghaffari co-founded MC10 Inc in 2008 (acquired by Medidata in 2020),[2] and was MC10's Chief Technology Officer until 2017.

Ghaffari then joined Northwestern University faculty where he is research associate professor[3] in the Department of Biomedical Engineering and is co-founder and CEO of Epicore Biosystems.

His research and commercial efforts have led to the development of novel classes of bioelectronic devices and microfluidic-based systems for commercial applications in sports performance, consumer health, and personalized care.