Her father fatally stabbed her mother when Rosa was a baby, and she was raised mainly by her paternal grandmother, Serena Corrothers Goodrich.

[5] Boido and her husband practiced medicine in Guatemala, El Salvador, Honduras, and Mexico[6] after earning their degrees in California.

[9] The Boidos moved to Phoenix in 1911, and opened the Twilight Sleep Hospital, specializing in obstetrics and gyneocology, but also offering general clinical services.

[4][10] Boido was active in the Woman's Christian Temperance Union of Arizona, and served as a delegate to the 1892 convention of the California Prohibitionist Party.

[1] In 1918 Boido was charged with performing an abortion at the Twilight Sleep Hospital, and found guilty;[15][16] she served two months in prison,[17] and lost her medical license.