Bishop Robert C. Morlino draws a connection to Isaiah 11:1, "But a shoot shall sprout from the stump of Jesse, and from his roots a bud shall blossom.

[1] This is also reflected in the German Advent hymn Es ist ein Ros entsprungen, known in English as ""Lo, how a rose e'er blooming", which makes reference to the Old Testament prophecies of Isaiah which in Christian interpretation foretell the Incarnation of Christ, and to the Tree of Jesse, a traditional symbol of the lineage of Jesus.

[2] A devotional image enshrined at the Maria Rosenberg Church in Waldfischbach-Burgalben, Germany, holds an 1138 painting of Mary, featuring roses.

Bernard of Clairvaux said, "Eve was a thorn, wounding, bringing death to all; in Mary we see a rose, soothing everybody's hurts, giving the destiny of salvation back to all."

Gerard Manley Hopkins wrote a devotional poem called "Rosa Mystica" (c.1874-5), which includes the lines "Mary the Virgin, well the heart knows, / She is the mystery, she is that rose".

[6] Chrysogonus Waddell composed an a capella choral piece titled "Rosa Mystica", which was featured in the 2017 film Lady Bird.

[7] On 7 December 2019, the Roman Catholic Diocese of Brescia inaugurated a shrine to the Blessed Virgin under the title Rosa Mystica – Mother of the Church.

These celebrations include the exposition of the Blessed Sacrament, the praying of the rosary, and the Holy Mass, in accordance with the Virgin's requests to Pierina during her apparitions.

In 1993, at the Sisters Servants of Jesus Convent in Carrizal, Miranda State, Venezuela, the Virgin Mary reportedly appeared to several people, including nuns, displaying various miraculous signs.