Rosanna Fratello was born in San Severo, Foggia, and as a child she moved to Cinisello Balsamo, Milan, where she has grown up.

[3] Her other roles were in the crime films The Black Hand (1973) and Cross Shot (1976).

In 1972, she topped the Hit Parade with her major success, the song "Sono una donna, non sono una santa";[1][2] in the following years she experimented with various genres such as disco music, folk music and Italo disco and competed in a number of Sanremo Festivals, but failed to repeat that success.

[1] In 1985, Fratello took part in the musical project "Ro Bo T" together with Bobby Solo and Little Tony.

[1] In 2023-2024, she participated in the seventeenth edition of Grande Fratello (the Italian version of Big Brother); as a result, her 1982 success "Se t'amo t'amo" (written by Cristiano Malgioglio) has become popular again.