She was elected into office as the first female representative from her constituency in June 2011 and sat as Deputy Chairman House Committee on Education.

Okoji Oko started her career in the Nigerian Youth Service Corps as a tutor in Edgerly Memorial Girls Secondary School, Calabar in 1981.

Between 1982 and 1983 she taught at St. Patricks College, Calabar and in the same year moved to become a lecturer at the Cross River School of Basic Studies Akampka.

[citation needed] In 1989 at the age of 33, she was recognized for her years of service and started her career as a public servant when she was appointed Commissioner of Education, Cross River State; a position she held till 1991.

In 1993 she was appointed Director General, National Defence & Security Council, Cabinet Secretariat under the military presidency.

In 2003 when Nigeria held the first democratic election since the handover of power from military to civilian rule, Okoji Oko contested as a senate candidate, Cross River State North Senatorial District under the NDP banner, a contest she lost to the PDP candidate at the time.

The others include; Stella Oduah, Oluremi Tinubu, Aishatu Dahiru, Uche Ekwunife, Akon Eyakenyi and Betty Apiafe.

[7] Senator Oko commenced a four-year tenure as Member House of Representatives, Yala/Ogoja Federal Constituency in June 2011.

That year she was appointed to the following committees: She was elected a Senator twice, representing Cross River North senatorial district.