Quong showed great interest in amateur theatricals, winning competitions and performing with the Melbourne Repertory Players until in 1924, at age 44, she won a scholarship to study drama in England.

Quong continued her acting career in the United States, and also delivered lectures on Chinese drama, art, and culture.

She performed primarily in theatre, but had several film roles to her credit, including a small part in Flower Drum Song.

The backbone of Quong's career in the United States was a series of one-woman shows, consisting of recitations, dramatic readings, and scenes from plays.

Quong was deeply interested in Chinese philosophy, and studied it for much of her life; her presentations frequently included material from the I Ching.