[15] In 2016, Villain signed with the famous Italian hip hop independent label Machete Empire Records, becoming the first female artist of the roster.

The first single with Republic Records, "Funeral Party",[27] was released on 20 July 2018 and was a mix between pop and dancehall,[28] the music video of the song was directed by the same Villain and was shot in Kingston, Jamaica.

[34] In 2020, Villain joined MeNext Agency,[35] signed a new record deal with Arista, Sony Music Italy,[36] and she released her first single in Italian,[37] named "Bundy".

[38] A couple months later, she released the official single in Italian titled "Il Diavolo Piange"; its music video was shot in New York and was directed by Joe Mischo, also known as Brume.

She appeared on "Stone Cold Digital", part of A Pale Blue Dot by Dreamshade, a Swiss melodic death metal band; the album was released in March 2021.

[43][44] On 13 April 2021, she announced her collaboration with Paco Rabanne, having been chosen as testimonial for the launch of the fragrance Lady Million Fabolous.

[58] On 12 November 2021, Villain released the single "Gangsta Love" featuring the Italian rapper Rosa Chemical via Columbia and Arista records Italy.

[59][60][61] On 10 December 2021, Billain's third collaboration with Guè Pequeno was released for the song "Piango sulla Lambo" included in the seventh album of the rapper titled Guesus.

[71][72] On 28 June 2022, Villain was chosen by the Italian rapper Fedez as one of the performing artists for the benefit concert Love Mi.

1 (Summer Edition); Villain is featured on the remix single "Travesuras" together MV Killa, Yung Snapp, Vale Lambo, and Fred De Palma.

[75][76] The official music video of "Rari", directed by Amedeo Zancanella, set in New York, and inspired by the movie Kill Bill was released on VEVO on 13 October 2022.

[78] On 18 November 2022, Italian rapper Ernia released his fourth studio album Io non ho paura; Villain is one of the writers of the single "Bella fregatura".

[79] On 25 November 2022, Irama released the deluxe edition of his album Il giorno in cui ho smesso di pensare with three new songs; one of them is "Canzoni tristi", where Villain is the featured artist.

The album includes 14 songs featuring Salmo, Tedua, Geolier, Carl Brave, Elisa, Tony Effe, and Guè.

[90][91] On 10 February 2023, Villain joined Rosa Chemical for the duets evening of the Sanremo Music Festival 2023 to cover "America" by Gianna Nannini, ranking eighth in the contest.

On 1 May 2023, Villain was one of the performers of the annual concert of Primo Maggio in Rome organized by CGIL, CISL and UIL for Labour Day.

[96] In June 2023, in conjunction with the announcement of her participation as a judge for the Netflix show Nuova Scena - Rhythm + Flow Italia together Fabri Fibra and Geolier, her single Lamette with Salmo was certified gold by FIMI.

[97][98][99] On 9 June 2023, Carl Brave released his new album Migrazioni, for the project the artist chose to work with Rose for the track "Rimpianti".

[108] On 9 December 2023, she was featured on the song "Hall of Fame" included in the joint album of Artie 5ive e Rondodasosa titled Motivation 4 The Streetz.

[116][113] She also featured on the songs "Balenciaga", from Tony Effe's second album Icon,[117] and "Non lo sai" by pop punk band La Sad.

[118] On 26 April, together with Tananai and Madame, she released the single "Ho fatto un sogno", a celebrative song for the 20th scudetto of soccer team Inter Milan.

[121] In July, she was the opening act for Coldplay's Italian shows for their Music of the Spheres World Tour at the Stadio Olimpico.

Villain is very inspired by film directors such as Quentin Tarantino, David Fincher, Stanley Kubrick, and Alfred Hitchcock.

[129] Those interests brought Villain to create her dark sound,[130] which mix rock and hip hop; she also inspired by artists such as Nirvana, Guns N' Roses, The Rolling Stones, Johnny Cash, The Notorious B.I.G., 2Pac,[131] Kanye West, Ty Dolla $ign, and Kid Cudi.