[1] Mbabazi holds a bachelor's degree in Education, obtained from Makerere University, in Kampala, Uganda.

[2] From 2009 until 2011 she served as the Head of the investment promotion department in the Rwanda Development Board.

In 2011, Rosemary Mbabazi was appointed a caretaker of Umubano Hotel and the chairperson of Soprotel, a joint venture company between governments of Rwanda and Libya.

[2] In February 2012, she was appointed the Permanent Secretary in the Ministry of Youth and ICT,[2] serving in that capacity until February 2017, when she was transferred to the Rwanda Ministry of Trade, Industry and East African Community Affairs (MINEACOM), as the permanent secretary.

[4] Rosemary Mbabazi has previously served as a member of the board of directors of Rwanda Revenue Authority.