Situated in the town of Roseworthy, South Australia, it was located 49 kilometres from Adelaide by rail.

[1] The station was built on land within the Hundred of Mudla Wirra that was purchased by landowners William and Grace Gartrell.

In 1960, grain silos were provided at the station yard, allowing goods trains to load wheat from the area for export.

Grain trains last used the silos at Roseworthy on 2 February 2007, and the remaining stored hoppers were collected on 11 October 2007.

The station remnants and railway line were included in Aurizon's purchase of One Rail Australia in 2022.