Roshtqal'a District (Russian: Рошткалинский район, romanized: Roshtkalinskiy rayon, Tajik: Ноҳияи Роштқалъа, romanized: Nohiyai Roshtqal'a, also spelled Roshtkala from Russian transliteration) is a district in eastern Tajikistan, in the south-western part of the Gorno-Badakhshan Autonomous Region (GBAO).

Roshtqal'a town, the district capital, is about 30 km upstream from Khorog.

The head of the river is the Jawshangoz plain where there were clashes between nomadic Kirghiz and settled Tajiks in the 18th and 19th centuries.

There is a ruined fort from the 2nd or 3rd century and views of Karl Marx Peak to the south.

The district has an area of about 4,300 km2 (2,000 sq mi) and is divided administratively into six jamoats.