[citation needed] The institute's lead researchers, Michael Mullan and Fiona Crawford,[2] were members of a team of scientists who discovered the first genetic errors causing Alzheimer's disease in 1991 in the APP gene in early onset familial cases.

Mullan and Crawford also discovered the Swedish mutation which has been incorporated into transgenic mice which are widely used to understand the disease and test new treatments.

In partnership with colleagues at Trinity College, Dublin led by Brian Lawlor, Archer and Institute scientists conducted an open label phase I/II trial of nilvadipine in mild to moderate Alzheimer's disease subjects.

[citation needed] The institute is currently housed in a 41,000 sq ft (3,800 m2) scientific research facility in Sarasota, Florida.

The institute facility contains mass spectrometry, pathology, microscopy, certified GMO testing, and chemistry labs.