When Merle Kearns resigned from the House to take a position under Governor Bob Taft, McGregor was one of over a dozen candidates who sought to replace her.
Despite not being recommended by Clark County Republicans, McGregor nonetheless received the appointment, and was seated in October 2005.
[4] McGregor easily defeated Democratic challenger Greg Krouse in the general election with 59.7% of the vote.
[5] Speaker of the House William G. Batchelder has named McGregor as a member of the Republican majority caucus' Policy Committee for the 129th General Assembly.
In February 2011, McGregor announced his intention to renew a bipartisan effort to ban discrimination in employment and housing based on sexual orientation or gender identity, an effort which passed the Ohio House in 2009 but failed in the state Senate.