Noble rose to mainstream popularity through making appearances on British television, particularly interviews and on panel shows such as Have I Got News for You.

In 2015, he made his musical theatre debut in The Producers and in 2018 was nominated for a Laurence Olivier Award for his performance in Young Frankenstein in the West End.

[2][7] Although he does often have a few set topics which he performs throughout a tour, he describes the planning for the entire show as "about four words on a piece of scrap paper".

His most famous example is in his Randomist tour, where he started to tell a story about him being interviewed after Live 8 near the beginning of a show in Newcastle, which he did not finish until the end of the performance, around two hours later.

[10] This relates to an earlier comment he made in his Regent's Park show, saying that his mind "Tends to wander off [the point] slightly", and later added that "[he] can open up too many tangents at once... it's a never-ending expanding spiral of possibilities.

He joined a clown troupe and sold balloons as a stilt-walker, before deciding to become a comedian after winning tickets to a comedy show.

Noble has been performing stand-up since the dyslexia diagnosis, and appeared in his local comedy club at the age of 15, despite licensing laws that prohibited him working there and forced him to leave through the kitchen.

[7] Noble studied performing arts at Newcastle College, after he told his careers adviser at school he wanted to be a comedian.

While performing in Edinburgh in September 2006 for his Fizzy Logic tour, a fight broke out during the gig, caused by a drunken member of the audience arguing with another.

[20] In 2007, Noble finished his Nobleism tour in the UK[21] with a show in Liverpool on 21 October 2007 which was screened live to 43 Vue cinemas.

[22] Upon walking offstage, Noble enquired if the broadcast had succeeded and was informed by a technician that "it worked perfectly... but we lost Aberdeen".

It is now traditional for the entire front row of an Edinburgh audience to place their shoes upon the stage during the interval, which causes Noble much amusement when he returns.

[24] Noble performed at the 2008 Latitude Festival and rounded off his set by leading everyone in the tent in a huge conga line (which quickly turned into a stampede) to a vegan food stand so they could all ask for pies and sausage rolls.

In 2012, Noble made his film debut in the fantasy comedy horror movie Stitches playing the titular character, an undead birthday clown out for revenge.

[29] In Australia, he has guested on such TV and radio shows as Network 10's Rove (Live),[28] The Panel,[28] Good News Week, Thank God You're Here, Studio 10, The Project, Would I Lie to You?

Upon reading one book, he found a photo of Mike Yarwood on one page, which he cut out and wore as a mask for a portion of the interview.

The show was broadcast as "Ross Noble's Australian Trip" on UK TV channel 5 from Monday 28 September 2009 at 10pm for 6 weeks, repeating at the same time on Fiver on the following Thursdays.

Described as an anti-travelogue around Britain, in the show Noble took the freestyle philosophy he embraces in his live shows and utilised his trademark audience participation gimmick and transferred it to television as he rode around the UK on his motorbike taking live requests on Twitter instructing him on where he should go next, making the road trip entirely unpredictable.

[39] He finished as the runner-up of the series, raising over $100,000 for his charity, the Australian Red Cross - Disaster Response and Recovery Fund.

[40] Noble made his musical theatre debut as Franz Liebkind in the 2015 UK tour of Mel Brooks' The Producers from May to July 2015.

He lived on a farm in St Andrews, a semi-rural town on the northern outskirts of Melbourne, Australia, until it was destroyed by 2009 Victorian bushfires along with all his material possessions.

[46] A keen biker and off-road rider, Noble is also a fan of MotoGP, WSBK, and The Isle of Man TT.

He has created an off-road track in the paddock at his home, and has a number of vehicles to use on it, including an FV433 Abbot SPG self-propelled gun.

He attended several track days in 2011, including Brands Hatch on the GP circuit as a guest of MSV aboard his Triumph Daytona 675R.

Following the 2009 Victoria bushfires, Noble has used the event in his act and donates profits from the sale of the show's programme/poster (or "postergram" as it is called) to a charitable fund to help those similarly affected.