In 1933, German football was re-organized into sixteen top-flight divisions and Rot-Weiß appeared in the Gauliga Südwest for three seasons between 1938 and 1941.

After the war occupying Allied authorities ordered the dissolution of all organizations in Germany, including sports and football associations.

In late 1945 the club was re-constituted as SG Bockenheim and in 1947, once again named Rot-Weiß, played a single season in the first division Oberliga Süd before being relegated.

Rot-Weiß competed as a third-tier side in the Amateurliga Hessen through most of the 1960s and 1970s with a single season cameo in the Regionalliga Süd (II) in 1968–69.

Under mounting financial pressure the team's performance slipped and by the mid-1990s they were playing fourth and fifth division football.