It is thought that the experiments were at least to some extent influenced by Justus von Liebig who had attended a meeting of the British Association at Liverpool in 1837.
Lawes took out patents on manure mixtures and began a factory to manufacture them in 1843, the same year that Joseph Henry Gilbert replaced Dobson who had moved to Australia.
In 1902 Daniel Hall moved from Wye College to become director, taking a lower salary to join an establishment lacking money, staff, and direction.
Hall decided that Rothamsted needed to specialise and was eventually successful in obtaining state support for agricultural research.
In 1912 E. John Russell, who had come from Wye in 1907, took over as director until 1943, overseeing a major expansion in the 1920s, when Sir William Gammie Ogg took over until 1958 and increasing the number of staff from 140 to 471 and creating new biochemistry, nematology, and pedology departments.
In 1919 Russell hired Ronald Fisher to investigate the possibility of analysing the vast amount of data accumulated from the "Classical Field Experiments."
Fisher analysed the data and stayed to create the theory of experimental design, making Rothamsted a major centre for research in statistics and genetics.
[11] A video appeal by scientists at Rothamsted led to over 6,000 people signing a "Don't destroy research" petition organised by Sense about Science.